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KMID : 0377619740270020181
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Korean Jungang Medical Journal
1974 Volume.27 No. 2 p.181 ~ p.186
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Experimental Studies on "Burn Toxin"
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Abstract
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The treatment of burn has been progress great deal by fluid therapy in last a couple of decades. There has however not dimminished the mortality of burn patient. This has made many researches to believe in existance of burn toxin. Since this possible existance of burn toxin, numerous papers of burn toxin has been published. Through receiving the papers, it was suggested that there may be certain relation between the toxin and steroid hormone. In order to clarify their relationship between burn toxin and steroid hormone following animal experimental mortality was carried out.
Diffusates were collected from subcutaneous air balloon of the back of rats after making third degree burn of the balloon skin at 30 min., 1 hour, 2 hours, 4 hours, 6 hours, 12 hours, 24 hours, 48 hours, and 72 hours interval following burn. The amount of protein in each diffusates was measured. Each diffusate was then injected to the mice intraperitoneally and also steroid injection (5 mg IM) into experimental animal groups.
The results are as follows;
The protein amount of diffusate was continuously increased by time progressing after burn.
The mortality rate of mice intraperitoneally injected the diffusates of experimental rat that has a steroid therapy after burn, has more dimminished than control group.
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